abstract：:1. The authors examined the regional cerebral distribution of [Tc-99m] HMPAO using single photon emission computed tomography (SPECT) in patients with major depression and in healthy controls. 2. 19 patients and 16 healthy controls had SPECT images of the brain acquired with 740 MBq (20 mCl) of [Tc-99m] HMPAO on a tri...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Mozley PD,Hornig-Rohan M,Woda AM,Kim HJ,Alavi A,Payer F,Amsterdam JD

更新日期：1996-04-01 00:00:00

abstract：:1. A statistically significant increased risk of schizophrenia for individuals born in winter has been reported. The increase risk is of the order of 5-15 percent. The seasonal effect is more marked among females. This winter birth effect suggests some environmental agents, probably a neuropathogen one, acting on the ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Dassa D,Azorin JM,Ledoray V,Sambuc R,Giudicelli S

更新日期：1996-02-01 00:00:00

abstract：:1. Phorbol 12-myristate-13-acetate (PMA), a protein kinase C activator, elevated cyclic AMP accumulation in EBV-transformed human B-lymphocytes, and potentiated isoproterenol-, prostaglandin- (PGE1), cholera toxin-, and forskolin-stimulated cyclic AMP accumulation. 2. The dopamine D1 receptor agonist, SKF38393 (10(-7)...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Natsukari N,Kulaga H,Baker I,Wyatt RJ,Masserano JM

更新日期：1996-01-01 00:00:00

abstract：:1. The acute effects of some of typical and atypical antipsychotic drugs on the dopamine release and metabolism in the dorsal striatum of freely moving rats were studied using transcerebral microdialysis technique. 2. Classical neuroleptic drugs haloperidol (0.05, 0.1 and 0.2 mg/kg), thioproperazine (0.1, 0.2 and 0.4 ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Rayevsky KS,Gainetdinov RR,Grekhova TV,Sotnikova TD

更新日期：1995-12-01 00:00:00

abstract：:1. Haloperidol increased the Met-enk level in the striatum at all age groups. However, the Met-enk level was decreased in AL of young and middle-aged rats by the drug. 2. Haloperidol elevated the beta-end level in AL and CCK level in NIL in young rats only. 3. The SP content in NIL was decreased by haloperidol in all ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Lau SM,Tang F

更新日期：1995-11-01 00:00:00

abstract：:1. The presence of mood disturbances and platelet 3H-imipramine binding, a putative peripheral serotonergic marker, were evaluated in a group of 27 cocaine users three days after drug withdrawal. 2. Parameters of cocaine use and the linkage between cocaine withdrawal and "post-cocaine depression" were also investigate...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Pathiraja A,Marazziti D,Cassano GB,Diamond BI,Borison RL

更新日期：1995-10-01 00:00:00

abstract：:1. To define the neural circuits activated by dopaminergic stimulation in rat models of parkinsonism, the author studied the effects of L-dopa and selective D1 and D2 agonists on RCGU in rats with unilateral 6-OHDA substantia nigra lesions. 2. Systemic administration of L-dopa markedly increased RCGU in the EP and SNr...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Trugman JM

更新日期：1995-09-01 00:00:00

abstract：:1. Lidocaine has been extensively investigated as a potential neuroprotective drug against ischemia-induced neurodegeneration without reaching any satisfactory conclusion. 2. The present work evaluates the effect of lidocaine -17 microM- on the hypoxia-induced release of tritiated D-aspartate from rat striatal slices ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Díaz L,Gómez A,Bustos G

更新日期：1995-09-01 00:00:00

abstract：:1. Evidence suggests catecholamines and indoleamines may play a role in the pathogenesis of several psychiatric disorders. These neurotransmitters (i.e. dopamine, norepinephrine and serotonin) are synthesized within the human brain from their precursors, the aromatic large neutral amino acids tyrosine and tryptophan. ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Lucca A,Lucini V,Catalano M,Smeraldi E

更新日期：1995-07-01 00:00:00

abstract：:1. The efficacy of butoctamide hydrogen succinate (BAHS) was compared with that of nitrazepam on the basis of the polysomnograms and the subjective assessments. 2. Twelve healthy male students were divided into three groups consisting of 4 subjects each with were administered BAHS 600 mg, nitrazepam 5 mg, and BAHS 600...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Mizuki Y,Suetsugi M,Hotta H,Ushijima I,Yamada M

更新日期：1995-05-01 00:00:00

abstract：:1. Male Sprague-Dawley rats were trained to discriminate 0.4 mg/kg nicotine subcutaneously administered from its saline vehicle in a food-motivated operant discrimination task. Once trained, the discriminative performance was observed to be dose-responsive with an ED50 = 0.11 mg/kg. 2. The co-administration of 0.1 or ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Schechter MD

更新日期：1995-05-01 00:00:00

abstract：:1. A sample of 165 schizophrenic subjects was compared to a normal control group in order to evaluate associations between white matter hyperintensity signals and vascular risk factors. 2. A comprehensive medical chart review was completed on all subjects evaluating potential vascular risk factors. Brain MRI acquisiti...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Brown FW,Lewine RR,Hudgins PA

更新日期：1995-01-01 00:00:00

abstract：:1. In order to examine the effects of corticosterone in the anxiety response, the effect of acute, subchronic and chronic corticosterone (CORT) administration were studied using two animal models to study anxiolytic effects of drugs: the elevated plus-maze and the blockade of pentylenetetrazol (PTZ)-induced clonic con...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Andreatini R,Leite JR

更新日期：1994-12-01 00:00:00

abstract：:1. The effects of chronic administration with milnacipran and desipramine on the noradrenergic alpha 2-autoreceptor sensitivity in the rat hypothalamus were compared. 2. Rats were administered, in their diet, milnacipran (50 mg/kg/day for 21 days, 24 h wash-out), desipramine (35 mg/kg/day for 21 days, 24 h wash out) o...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Moret C,Briley M

更新日期：1994-10-01 00:00:00

abstract：:1. Delta TSH, REM latency, 4 pm and 11 pm post-dexamethasone cortisol values were determined after a wash-out period in a group of 74 non-selected depressed patients who were diagnosed (according to RDC with the SADS) as follows: 46 definite and 10 probable MD, 4 minor and 14 intermittent depression. 2. These biologic...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Staner L,Linkowski P,Mendlewicz J

更新日期：1994-09-01 00:00:00

abstract：:1. A simple summary measure--namely, cumulative mean change (CMC)--is proposed for analyzing incomplete repeated measures in clinical settings. 2. A simple test statistic that uses the correlation between subject responses was derived and applied to a study comparing an investigational antidepressant, venlafaxine, wit...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Entsuah AR,Bradley MM,Littman GS

更新日期：1994-07-01 00:00:00

abstract：:Recent case reports of postpartum psychosis are reviewed, which suggest hypotheses for the aetiology of this disease. The main themes are: The relationship to manic depression. Premenstrual relapse. Prepartum onset. Onset after miscarriage or evacuation of a trophoblastic tumour. Onset after bromocriptine treatment. A...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Brockington IF,Meakin CJ

更新日期：1994-05-01 00:00:00

abstract：:A variety of antidepressants of different chemical classes were tested for their in vivo and in vitro activity at 5-HT1C receptors in the brain. Conventional tricyclic antidepressants (imipramine, desipramine, maprotiline, clomipramine, trimipramine, amitriptyline, nortriptyline, doxepin, amoxapine, oxaprotiline) and ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Jenck F,Moreau JL,Mutel V,Martin JR

更新日期：1994-05-01 00:00:00

abstract：:1. The specificity of negative symptoms remains an open question and requires further research. 2. Subtyping negative symptoms has been showed to be a very relevant point for the identification of primary negative symptoms and for their pharmacotherapy. Negative symptoms as a whole have been demonstrated in schizophre...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Gerbaldo H,Helisch A,Schneider B,Philipp M,Benkert O

更新日期：1994-03-01 00:00:00

abstract：:1. Clinical response to treatment with haloperidol was studied in 20 schizophrenic inpatients with acute exacerbation (DSM-IIIR). 2. Patients were assigned to fixed doses of haloperidol (10, 20 or 30 mg/day) for three weeks. Clinical assessment was made using scales SAPS, SANS, BPRS and Simpson-Angus Scale for rating ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Palao DJ,Arauxo A,Brunet M,Marquez M,Bernardo M,Ferrer J,Gonzalez-Monclus E

更新日期：1994-01-01 00:00:00

abstract：:1. The majority of neurons in the striatum (caudate-putamen, dorsal striatum; nucleus accumbens, ventral striatum) and in striatal projection regions (the pallidum, the entopeduncular nucleus and substantia nigra reticulata) use gamma-aminobutyric acid (GABA) as transmitter and express glutamic acid decarboxylase (GAD...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Lindefors N

更新日期：1993-11-01 00:00:00

abstract：:1. In lower vertebrates, optic fibers form a highly ordered retinotopic projection to the contralateral midbrain. 2. The formation of fine retinotopy during development or regeneration requires patterned impulse activity in optic fibers. 3. The transmitter used by optic fibers is probably glutamate. 4. Blockade of NMD...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Meyer RL

更新日期：1993-09-01 00:00:00

abstract：:1. The authors attempted to detect a possible effect of treatment with phenelzine on a physiological response to nicotine in the rat. 2. Positive findings in an animal model suggest the feasibility of more complicated experiments in animals and the possibility of studies involving human subjects. 3. Treatment of Sprag...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Dilsaver SC,Hariharan M,Davidson RK

更新日期：1993-09-01 00:00:00

abstract：:1. Studies in our laboratory have used the psychoendocrine strategy to explore differences in basal hormone levels between patients with posttraumatic stress disorder (PTSD) and other groups. This approach has allowed us to explore the relationship between hormone levels and specific psychological and biological proce...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Yehuda R,Giller EL Jr,Mason JW

更新日期：1993-07-01 00:00:00

abstract：:1. It has been postulated that the interrelated processes of neurodegeneration, neuroplasticity, and neuroimmunological abnormalities may play a role in the pathophysiology of schizophrenia. Since, interleukins are produced in the central nervous system and have cytokine and growth promoting properties, they are an ob...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： el-Mallakh RS,Suddath RL,Wyatt RJ

更新日期：1993-05-01 00:00:00

abstract：:1. Clinical data suggest that valproate (VPA) may be useful in prophylaxis of affective disorders, which show disturbances of the serotoninergic system. On the other hand, chronic stress has an adverse effect on affective disorders, those with disturbances of the serotonergic system, especially. 2. In order to study t...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Mitsikostas D,Sfikakis A,Papadopoulou-Daifoti Z,Varonos D

更新日期：1993-03-01 00:00:00

abstract：:1. Interaction between iron and melanin may provide a reasonable explanation for the vulnerability of the melanin containing dopaminergic neurons in the substantia nigra (SN) to neurodegeneration in Parkinson's disease (PD). 2. Scatchard analysis of the binding of iron to synthetic dopamine melanin revealed a high-aff...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Ben-Shachar D,Youdim MB

更新日期：1993-01-01 00:00:00

abstract：:1. The effects of chemically induced convulsions, clinically similar to those elicited by electroconvulsive treatment (ECT), on brain regional distribution of neuropeptide Y-, neurokinin A-, substance P- and neurotensin-like immunoreactivities were studied in the rat. 2. Pentylenetetrazole (PTZ) and bicuculline (BIC) ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Stenfors C,Theodorsson E,Mathé AA

更新日期：1992-09-01 00:00:00

abstract：:1. The neuroleptic malignant syndrome was initially described as a disorder specifically related to neuroleptic usage with frequent fatal outcome. The observations of variant or mild cases of this syndrome as well as case reports on neuroleptic-malignant-like syndromes in the absence of neuroleptics raises the issue o...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Gratz SS,Levinson DF,Simpson GM

更新日期：1992-07-01 00:00:00

abstract：:1. Leukocyte enumeration through flow cytometry has revealed that severe depression may be accompanied by a systemic immune activation, indicative of an inflammatory response. The latter condition allegedly involves an important modification of acute phase plasma protein (APP) equilibrium. 2. In order to elucidate whe...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Maes M,Scharpe S,Bosmans E,Vandewoude M,Suy E,Uyttenbroeck W,Cooreman W,Vandervorst C,Raus J

更新日期：1992-07-01 00:00:00

abstract：:1. Two classes of GABAergic inhibitory interneurons, chandelier and basket cells, are known regulators of pyramidal neurons. Parvalbumin (PV) a calcium binding protein, has been shown to be a marker for axon terminals of subpopulations of these interneurons. 2. Immunohistochemical methods were used in this study to ex...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Akil M,Lewis DA

更新日期：1992-05-01 00:00:00

abstract：:1. The authors report three cases of neuroleptic induced akathisia resistant to treatment with anticholinergics, benzodiazepines and betablockers. 2. All three patients were treated with Ritanserin 10 mg bid and improved rapidly and substantially. 3. Discontinuation of Ritanserin led to a recurrence of akathisia. ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Miller CH,Hummer M,Pycha R,Fleischhacker WW

更新日期：1992-03-01 00:00:00

abstract：:1. Male hooded Lister rats were fed a liquid diet containing 10% absolute ethanol for 4-5 weeks. Control rats received the liquid diet in amounts controlled to produce equal weight gain. 2. The rats were tested 7.5 h after withdrawal of ethanol and 30 min after i.p. injection with nitrendipine, chlordiazepoxide or bac...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： File SE,Zharkovsky A,Hitchcott PK

更新日期：1992-01-01 00:00:00

abstract：:1. The UN Convention 1971 on Psychotic substances requires the World Health Organization to recommend psychotropic substances for international control. 2. This convention is based on evaluating the benefit and risk ratio, in particular on the public health and social problems associated with its use. 3. The UN Commis...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Khan I

更新日期：1992-01-01 00:00:00

abstract：:The P3 component of a visual event related potential (ERP) was studied for five consecutive weeks in six women with normal menstrual cycles. Serum concentrations of luteinizing hormone (LH), estradiol (E2) and progesterone were studied during the same period. Increases in P3 amplitude, although nonsignificant, were no...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kluck N,O'Connor S,Hesselbrock V,Tasman A,Maier D,Bauer L

更新日期：1992-01-01 00:00:00

abstract：:Negative symptoms have been associated with structural impairment in the PFC, and hypothesized to arise from a central hypodopaminergic substrate. Corticofugal PFC neurons, which are inhibited by VTA DA innervation, exert a tonic excitatory modulation on DA activity in the NAS. Lesions of ascending DA forebrain projec...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Lynch MR

更新日期：1992-01-01 00:00:00

abstract：:1. Azapirones, selective partial agonists at the 5-HT1A receptor subtype, induce hypothermia and corticotropin (ACTH)/cortisol release as specific functional correlates of central 5-HT1A receptor activation. 2. Compared to controls, hypothermic and ACTH/cortisol responses to the azapirone ipsapirone are attenuated in ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Lesch KP

更新日期：1991-01-01 00:00:00

abstract：:1. Chronic treatment with amitriptyline produces supersensitivity to the hypothermic effects of the muscarinic agonist oxotremorine. 2. Chronic treatment with amitriptyline also produces supersensitivity to the hypothermic effects of nicotine. 3. Oxotremorine and other naturally occurring muscarinic agonists are also ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Dilsaver SC,Majchrzak MJ,Snider RM,Davidson RK

更新日期：1991-01-01 00:00:00

abstract：:1. Twenty-two patients hospitalized for treatment of depression were treated under conditions simulating those of home treatment. 2. Full doses of nortriptyline, from 100 to 150 mg/day, were started after baseline observations were made. 3. Two patients were dropped from the study, one for orthostatic hypotension, one...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Peabody C,Van Norman J,Hollister L,Warner D

更新日期：1991-01-01 00:00:00

abstract：:1. Phenylethylamine has been proposed as a neuromodulator in several psychiatric and other brain disorders, and its concentration and that of its major metabolite, phenylacetic acid, in plasma may prove useful as state or trait markers in diagnosis, treatment or in the elucidation of biochemical mechanisms of these di...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Davis BA,O'Reilly RL,Placatka CL,Paterson IA,Yu PH,Durden DA

更新日期：1991-01-01 00:00:00